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AOE or insane DPS, pretty much. Don't let the side-blobs get out of control, but don't ignore the main mass either. AOE makes that really easy...

Have something to manage the blobs (even a single target skill can work since they need to be directly linked to the main body) and keep the...

Secret: fighter's overkill-to-explosion skill explodes when you kill the tumor things while it's trapped. You forger Arthur. Arthur when he was...

Easiest way is probably with a ranger with the scatter shot or a mage with meteor swarm. I just did the quest where and my butcher who was kind...

sorry for kind of late response, the specific "fuck you" option is a hunter with rubber arrows/rubber cement and scatter shot, then aim scatter...